Nongenomic Mechanisms of Sex Hormones

摘要: Following the isolation and identification of steroid hormones in first half this century, their mechanism(s) action have been under investigation. The development radiolabelled ligands allowed specific binding proteins, present intracellularly, that were translocated to nucleus after with steroid. location steroid-protein complex suggested a link between phenomenom transcriptional activity as explanation physiological [1]. Further studies indeed demonstrated exerted biological these high-affinity named receptors, induced an allosteric change receptor-protein enabled steroid-receptor bind sites on chromatin modulate activity. It became established act at level nuclear DNA they are involved regulation gene expression.