Early lesions in experimental bladder cancer: experimental design and light microscopic findings.

摘要: Summary N -[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide (FANFT) fed to male and female Fischer rats at a dose of 0.2% the diet induces lesions urinary bladder which progress from mild hyperplasia 2 4 weeks, moderate 6 8 severe nodular papillary 10 14 microinvasive carcinomas by 25 weeks as observed light microscopy. Male FANFT for or then maintained on control show regression within normal-appearing mucosa persists through 50 weeks. Rats moderately hyperplastic epithelium normal after being placed receiving diet, but focal areas are detectable 20th week experiment. By 50th all had marked hyperplasia, transitional cell tumors, one was invasive entire thickness wall. The present in 12, 14, 20 continued tumors (microinvasive invasion muscle) been Thus, developing administration appear be reversible if is discontinued, later irreversible.