Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial

摘要: OBJECTIVE —The purpose of this study was to evaluate whether severe hypoglycemia or intensive therapy affects cognitive performance over time in a subgroup patients who were aged 13–19 years at entry the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS —This longitudinal involving 249 with type 1 diabetes between 13 19 old when they randomly assigned DCCT. Scores on comprehensive battery tests obtained during Epidemiology Interventions follow-up study, ∼18 later, compared baseline performance. We assessed effects original DCCT treatment group assignment, mean A1C values, frequency hypoglycemic events eight domains cognition. RESULTS —There total 294 reported episodes coma seizure. Neither nor previous associated decline any domain. As analysis entire cohort, higher values declines psychomotor mental efficiency domain ( P CONCLUSIONS —Despite relatively high rates hypoglycemia, function did not an extended period youngest cohort diabetes.