Effect of 6‐Hydroxydopamine Lesions of the Medial Prefrontal Cortex on Neurotransmitter Systems in Subcortical Sites in the Rat
作者： C. J. Pycock , C. J. Carter , R. W. Kerwin
DOI: 10.1111/J.1471-4159.1980.TB04625.X
关键词: Endocrinology 、 Chemistry 、 Dopamine 、 Glutamate decarboxylase 、 Prefrontal cortex 、 Internal medicine 、 Cerebral cortex 、 Norepinephrine 、 Neuroscience 、 Hydroxydopamine 、 Choline acetyltransferase 、 Basal ganglia
摘要: The effect of lesions the catecholamine nerve terminals in medial prefrontal cortex rat on neurotransmitter mechanisms within basal ganglia has been investigated. Bilateral 6-hydroxydopamine were stereotaxically placed dopamine-rich (DA) area th frontal cortex. Animals pretreated with desmethylimipramine to block uptake neurotoxin into noradrenergic (NA) and make it more selective for DA terminals. lesion produced a reduction both NA from cortex, result related falls tyrosine hydroxylase activity at this site. Lesioned animals showed enhanced turnover utilisation striatal limbic regions. There was no change subcortical activity. In addition there significant other putative neurotransmitters sites, including 5-hydroxytryptamine GABA. Decreased neurotransmitter-synthesizing enzyme glutamate decarboxylase choline acetyltransferase also recorded certain regions ganglia. results suggest that cortical systems may serve regulate various
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