Enhancement of the Therapeutic Capacity of Mesenchymal Stem Cells by Genetic Modification: A Systematic Review.

摘要: Background: The therapeutic capacity of mesenchymal stem cells (also known as stromal cells/MSCs) depends on their ability to respond the need damaged tissue by secreting beneficial paracrine factors. MSCs can be genetically engineered express certain aim this systematic review is compile and analyze published scientific literatures that report use for treatment various diseases/conditions, discuss mechanisms action, assess efficacy MSC treatment. Methods: We retrieved all studies in PubMed/MEDLINE Cochrane Library July 27, 2019, without time restriction using following keywords: “engineered MSC” “therapy” or “manipulated “therapy.” In addition, relevant articles were found during full text search added. identified 85 reviewed paper. Results: Of reviewed, 51 reported treat tumor/cancer/malignancy/metastasis, whereas other 34 tested treating nontumor conditions. Most animal models, with only one study reporting a trial human subjects. Thirty nine showed expression factors would significantly enhance effects MSCs, thirty three moderate effects, humans no effect. action MSC-based cancer include “suicide genes,” induction tumor cell apoptosis, delivery cytokines induce an immune response against cells. context noncancerous diseases, mechanism described papers included angiogenic, osteogenic, growth Conclusion: enhanced inducing genetic modification. Genetically have been used successfully models diseases. However, results should interpreted cautiously because might not perfectly represent real Therefore, further are needed explore translational potential MSCs.