Reducing the risk of fractures with calcium and vitamin D.
作者： O. Sahota
DOI: 10.1136/BMJ.B5492
关键词: Medicine 、 Hazard ratio 、 Confidence interval 、 Vitamin D and neurology 、 Gastroenterology 、 Calcium 、 Hip fracture 、 Internal medicine 、 Dosing 、 Randomized controlled trial 、 Surgery 、 Increased risk
摘要: The combination is more effective than vitamin D alone Conflicting evidence exists on the role of D, either alone or in with calcium, reducing fractures. Some studies have shown a reduction risk fractures, others no effect, and one recent study found an increased hip fracture.1 best dose to use, which patients benefit most, fractures are most amenable such treatment remain clinical dilemma. In linked (doi:10.1136/bmj.b5463), DIPART (vitamin Individual Patient Analysis Randomized Trials) group reports individual patient data analysis aimed at identifying factors that influence efficacy plus calcium also assessed dosing regimens coadministration calcium. looked seven randomised controlled trials (n=68 517)—six were individually was cluster randomised.2 It using (low high dose) combined reduced overall fracture (hazard ratio 0.92, 95% confidence interval 0.86 0.99), but only low (10 μg) (0.74, 0.60 0.91). They …
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