Splenic anti-inflammatory reflex in immune tolerance.

摘要: Abstract The injection of repeated doses lipopolysaccharide (LPS) results in attenuation the immune response, which is an important mechanism to prevent deleterious long-term excessive inflammation. Brain-mediated mechanisms are involved this endogenous anti-inflammatory effect, but nothing known about putative role splenic reflex (which has recently been described as a powerful suppression response) during tolerance. Therefore, we tested hypothesis that endotoxin tolerance at least part mediated by reflex. Body core temperature (Tb) was measured rats previously submitted splenectomy. Immune induced means five consecutive LPS (100 μg/kg) intraperitoneal injections 24-h intervals. In sham operated rats, observed significant reduction febrile response administration LPS, not altered Moreover, plasma pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6] prostaglanding E2 (PGE2) surges besides preoptic PGE2 levels were after first tolerant animals, pattern kept same splenectomized rats. These data consistent with notion does modulate