EEG profile and behavioral changes after a single dose of clozapine in normals and schizophrenics.

摘要: Clozapine, a powerful neuroleptic with unique clinical efficacy (and without parkinsonic side effects), has been shown to have an unusual EEG profile. The changes after clozapine, especially when instrumentally quantified, demonstrated the predictive value of EEG. similarities profile clozapine thymoleptic compounds indicated its possible effect. This later proved be case therapeutic studies in depression. volunteers is similar schizophrenics (with appropriately higher doses). Instrumental quantification was performed spectral and iterative interval analysis show advantages each method also complementary both them.