Direct Identification and Characterization of β-Adrenergic Receptors and Functional Relationship of Adenylyl Cyclase
作者： E.M. BROWN , A.M. SPIEGEL , J.D. GARDNER , G.D. AURBACH
DOI: 10.1016/B978-0-12-526303-0.50010-2
关键词: Adenylyl cyclase 、 Hormone receptor 、 Chemistry 、 Poor correlation 、 Biochemistry 、 Receptor 、 Stereospecificity 、 β adrenergic receptor 、 Identification (biology)
摘要: Publisher Summary This chapter provides an overview of the direct identification and characterization β-adrenergic receptors functional relationship adenylyl cyclase. Since past several years, a variety radioactive ligands have been employed to identify hormone in number different tissues. Earlier attempts study interactions with labeled agonists met methodologie problems, including lack stereospecificity poor correlation between binding data biological effects. However, recently development high-specific-activity blockers has permitted β-receptors properties expected from physiological studies, saturability, strict stereospecificity, parallelism inhibition tracer activation or
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