Distribution of chromogranin and S100 protein in normal and abnormal adrenal medullary tissues.

摘要: The distribution of chromogranin and S100 protein was studied in 30 adrenal pheochromocytomas 19 normal medullary tissues. Immunostaining the tumors compared with staining sections histologically medullae. Chromogranin showed diffuse cytoplasmic all chromaffin cells. consistently more intense medullae, while less present most from four groups. cytoplasm nuclei sustentacular cells surrounding nerve branches. Many protein-positive were two hyperplastic patients multiple endocrine neoplasia, type 2. Very few other pheochromocytomas. These results indicate that may be helpful separating 2 disease benign malignant sporadic tumors.