Parathyroid Hormone (PTH)
作者： Thomas J. Gardella , Henry M. Kronenberg
DOI: 10.1016/B0-12-475570-4/00984-7
关键词: Parathyroid hormone 、 Biological activity 、 Receptor 、 Endocrinology 、 Osteoporosis 、 Parathyroid hormone receptor 、 Kidney 、 Calcium metabolism 、 Internal medicine 、 Peptide hormone 、 Chemistry
摘要: Parathyroid hormone (PTH) is an 84-amino-acid polypeptide that plays a key role in the regulation of ionized calcium and phosphate blood extracellular fluids. It binds to signals through G protein-coupled receptor, PTH-1 on bone kidney cells. The first 34 amino acids PTH determine its biological activity. Abnormalities secretion or action result hypercalcemia hypocalcemia; can have anabolic effects thus holds promise for treatment osteoporosis.
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