Correlated activity of cortical neurons survives extensive removal of feedforward sensory input

摘要: A fundamental property of brain function is that the spiking activity cortical neurons variable and some this variability correlated between neurons. Correlated not due to stimulus arises from shared input but neuronal circuit mechanisms result in these noise correlations are fully understood. Here we tested visual system if mid-level area V4 cortex altered following extensive lesions primary (V1). To end recorded longitudinally two behaving macaque monkeys before after a V1 lesion while fixated grey screen. We found survived both monkeys. In one monkey, correlation multi-unit signals was strongly increased first week post-lesion, second slightly increased, greater than week-by-week fluctuations observed. The typical drop-off inter-neuronal with distance preserved lesion. Therefore, as remain without feedforward V1, results suggest instead local and/or feedback seem be necessary for activity.