Impact of an aryl bulky group on a one-pot reaction of aldehyde with malononitrile and N-substituted 2-cyanoacetamide

作者: Divyang M. Patel , Mayank G. Sharma , Hitendra M. Patel , Ruturajsinh M. Vala

DOI: 10.1039/C9RA05975J

关键词: Steric effectsGroup (periodic table)AldehydeChemistryMedicinal chemistryCatalysisMalononitrileArylOne pot reactionKnoevenagel condensation

摘要: In this study, we successfully explored the effect of steric hindrance on one-pot reaction different aryl aldehydes with malononitrile and N-substituted 2-cyanoacetamide in presence piperidinium acetate as catalyst. It involved Knoevenagel condensation aldehyde to produce arylidene an intermediate, which was further treated give 6-amino-2-pyridone-3,5-dicarbonitrile derivatives when less bulky group involved. High changed earlier route gave 2-cyanoacrylamides via a slower route.

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