Chaperoning steroid hormone action

作者: Didier Picard

DOI: 10.1016/J.TEM.2006.06.003

关键词: Nuclear receptorCell signalingBioinformaticsAllosteric regulationChaperone (protein)Steroid hormoneReceptorNeuroscienceHsp90HormoneBiology

摘要: Those that efface themselves in the action tend to be forgotten. But molecular chaperones are always there, often serving as equal partners. Because of their intrinsic functional frailty, a large number signaling molecules have come depend on chaperones, notably Hsp90 chaperone machine. This applies subset nuclear receptors converts steroid hormone signals transcriptional outputs. Steroid appear rely machine for folding, regulation allosteric switch and recycling. review discusses complexities machinery diversity regulatory options afforded by this assistance action.

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