作者: Didier Picard
DOI: 10.1016/J.TEM.2006.06.003
关键词: Nuclear receptor 、 Cell signaling 、 Bioinformatics 、 Allosteric regulation 、 Chaperone (protein) 、 Steroid hormone 、 Receptor 、 Neuroscience 、 Hsp90 、 Hormone 、 Biology
摘要: Those that efface themselves in the action tend to be forgotten. But molecular chaperones are always there, often serving as equal partners. Because of their intrinsic functional frailty, a large number signaling molecules have come depend on chaperones, notably Hsp90 chaperone machine. This applies subset nuclear receptors converts steroid hormone signals transcriptional outputs. Steroid appear rely machine for folding, regulation allosteric switch and recycling. review discusses complexities machinery diversity regulatory options afforded by this assistance action.