ENDOTHELIAL CELL REGULATION OF CONTRACTILITY OF THE HEART
作者： Saul Winegrad
DOI: 10.1146/ANNUREV.PHYSIOL.59.1.505
关键词: Contractility 、 Endothelin receptor 、 Contraction (grammar) 、 Biophysics 、 Biology 、 Internal medicine 、 Endothelium 、 Endothelins 、 Endothelial stem cell 、 Signal transduction 、 Endocrinology 、 Myocyte
摘要: Endocardial and coronary vascular endothelial cells release substances that modify the contraction of cardiac myocytes. The major possibly sole up-regulating substance is endothelin. Several down-regulating are secreted, but none has yet been specifically identified. relative amounts up- related to tissue oxygen tension. As pO2 rises, concentration substances, respectively, increases decreases. Endothelin isometric force decreases actomyosin ATPase activity thus increasing economy conversion chemical hydrodynamic energy. Beta-adrenergic agonists increase through an cell-dependent mechanism, leading decreased economy. Therefore, two systems exist for regulating contractile efficiency: One involving endothelin appears optimize efficiency; other, beta-adrenergic-mediated system, optimizes power.
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