Long-term histologic and virologic outcomes of acute self-limited hepatitis B.
作者： N Yuki
关键词: Immunology 、 Hepadnaviridae 、 Liver function 、 Hepatitis B 、 HBsAg 、 Hepatitis B virus 、 Antibody 、 Orthohepadnavirus 、 Viral load 、 Medicine
摘要: The long-term impact of acute self-limited hepatitis B on the liver is unknown. Fourteen patients were recalled at a median 4.2 years (range, 1.8-9.5 years) after onset B. All showed clinical and serologic recovery with circulating surface antigen (HBsAg) clearance. Antibody to HBsAg (anti-HBs) had developed in 12 patients. Nine underwent biopsies 7.2 years, histologic findings evaluated using Ishak scores. Serum samples frozen tissue subjected real-time detection polymerase chain reaction (PCR) quantify X regions virus (HBV) genome qualitative PCR detect covalently closed circular (ccc) HBV DNA replicative intermediate. Three low levels up 8.9 onset, whereas both found all 9 examined, including 7 negative for serum DNA. Liver viral loads assessed by 2 significant correlation (r = 0.946; P .008), tested positive ccc fibrosis mild inflammation persisted 8 stage relation peak phase (P .046) but not late convalescent phase. In conclusion, occult infection persists accompanied abnormal histology decade complete from
sci-hub.se 参考文章(26)
Hideki Hagiwara, Norio Hayashi, Eiji Mita, Tetsuo Takehara, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada, Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy Gastroenterology. ,vol. 104, pp. 877- 883 ,(1993) , 10.1016/0016-5085(93)91025-D
Mary Kuhns, Anne McNamara, Andrew Mason, Carolyn Campbell, Robert Perrillo, Serum and liver hepatitis B virus DNA in chronic hepatitis B after sustained loss of surface antigen. Gastroenterology. ,vol. 103, pp. 1649- 1656 ,(1992) , 10.1016/0016-5085(92)91191-6
Francis V. Chisari, Viruses, Immunity, and Cancer: Lessons from Hepatitis B American Journal of Pathology. ,vol. 156, pp. 1117- 1132 ,(2000) , 10.1016/S0002-9440(10)64980-2
Kamal Ishak, Amelia Baptista, Leonardo Bianchi, Francesco Callea, Jan De Groote, Fred Gudat, Helmut Denk, Valeer Desmet, Gerhard Korb, Roderick N.M. MacSween, M.James Phillips, Bernard G. Portmann, Hemming Poulsen, Peter J. Scheuer, Martin Schmid, Heribert Thaler, Histological grading and staging of chronic hepatitis. Journal of Hepatology. ,vol. 22, pp. 696- 699 ,(1995) , 10.1016/0168-8278(95)80226-6
Andrew L. Mason, Lizhe Xu, Linsheng Guo, Mary Kuhns, Robert P. Perrillo, Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen Hepatology. ,vol. 27, pp. 1736- 1742 ,(1998) , 10.1002/HEP.510270638
Barbara Rehermann, Carlo Ferrari, Claudio Pasquinelli, Francis V. Chisari, The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T–lymphocyte response Nature Medicine. ,vol. 2, pp. 1104- 1108 ,(1996) , 10.1038/NM1096-1104
Tse-Ling Fong, Adrian M. Di Bisceglie, Michael A. Gerber, Jeanne G. Waggoner, Jay H. Hoofnagle, Persistence of hepatitis B virus DNA in the liver after loss of HBsAg in chronic hepatitis B Hepatology. ,vol. 18, pp. 1313- 1318 ,(1993) , 10.1002/HEP.1840180605
T. Jake Liang, Hubert E. Blum, Jack R. Wands, Characterization and biological properties of a hepatitis B virus isolated from a patient without hepatitis B virus serologic markers Hepatology. ,vol. 12, pp. 204- 212 ,(1990) , 10.1002/HEP.1840120205
Jonas Bläckberg, Karin Kidd-Ljunggren, Occult hepatitis B virus after acute self-limited infection persisting for 30 years without sequence variation Journal of Hepatology. ,vol. 33, pp. 992- 997 ,(2000) , 10.1016/S0168-8278(00)80134-8
A Penna, M Artini, A Cavalli, M Levrero, A Bertoletti, M Pilli, F V Chisari, B Rehermann, G Del Prete, F Fiaccadori, C Ferrari, Long-lasting memory T cell responses following self-limited acute hepatitis B. Journal of Clinical Investigation. ,vol. 98, pp. 1185- 1194 ,(1996) , 10.1172/JCI118902