Amphetamine, haloperidol, and experience interact to affect rate of recovery after motor cortex injury

作者: D. Feeney , A Gonzalez , W. Law

DOI: 10.1126/SCIENCE.7100929

关键词: AnesthesiaMotor cortexParesisHaloperidolDextroamphetamineParalysisBrain damageMedicineNarrow beamAmphetamine

摘要: Rats subjected to unilateral ablation of the motor cortex and placed on a narrow beam displayed transient contralateral paresis. An immediate enduring acceleration recovery was produced by single dose d-amphetamine given 24 hours after injury. This effect blocked haloperidol or restraining animals for 8 beginning immediately amphetamine administration. A injury markedly slowed recovery. also animals.

参考文章(22)
Feeney Dm, Gonzales A, Law Wa, Amphetamine restores locomotor function after motor cortex injury in the rat. Proceedings of the Western Pharmacology Society. ,vol. 24, pp. 15- 17 ,(1981)
J. Jay Braun, Patricia M. Meyer, Donald R. Meyer, Sparing of a brightness habit in rats following visual decortication. Journal of Comparative and Physiological Psychology. ,vol. 61, pp. 79- 82 ,(1966) , 10.1037/H0022854
Takuji Kasamatsu, John D. Pettigrew, Preservation of binocularity after monocular deprivation in the striate cortex of kittens treated with 6-hydroxydopamine. The Journal of Comparative Neurology. ,vol. 185, pp. 139- 161 ,(1979) , 10.1002/CNE.901850109
Norman R. F. Maier, The cortical area concerned with coordinated walking in the rat The Journal of Comparative Neurology. ,vol. 61, pp. 395- 405 ,(1935) , 10.1002/CNE.900610209
Nils-Erik Andén, Sherrel G. Butcher, Hans Corrodi, Kjell Fuxe, Urban Ungerstedt, Receptor activity and turnover of dopamine and noradrenaline after neuroleptics European Journal of Pharmacology. ,vol. 11, pp. 303- 314 ,(1970) , 10.1016/0014-2999(70)90006-3
Roger M. Brown, Arvid Carlson, Bengt Ljunggren, Bo K. Siesjö, Stuart R. Snider, Effect of Ischemia on Monoamine Metabolism in the Brain Acta Physiologica Scandinavica. ,vol. 90, pp. 789- 791 ,(1974) , 10.1111/J.1748-1716.1974.TB05647.X
Takuji Kasamatsu, John D. Pettigrew, Marylouise Ary, Restoration of visual cortical plasticity by local microperfusion of norepinephrine. The Journal of Comparative Neurology. ,vol. 185, pp. 163- 181 ,(1979) , 10.1002/CNE.901850110
Robert D. Hall, Ernest P. Lindholm, Organization of motor and somatosensory neocortex in the albino rat Brain Research. ,vol. 66, pp. 23- 38 ,(1974) , 10.1016/0006-8993(74)90076-6