The molecular basis for abnormal human lung development.

摘要: Our understanding of lung development in the past two decades has moved from an anatomical to a histological basis and, most recently, molecular basis. Tissue interactions specify tracheal and primordia formation, program branching morphogenesis airway epithelium regulate epithelial differentiation. In addition, is influenced by mechanical humoral factors. The regulatory molecules involved morphogenetic signaling include growth transcription factors extracellular matrix molecules. These signals are responsible for patterning We will provide brief overview during early respiratory branching, pulmonary vascularization then review aberrant human abnormalities, such as tracheoesophageal fistula, congenital diaphragmatic hernia, hyperplasia, alveolar capillary dysplasia, cystic adenomatoid malformation bronchopulmonary dysplasia.