Myelofibrosis in Chronic Myeloproliferative Disorders: Incidence Among Subtypes According to the Hannover Classification
作者： T. Buhr , A. Georgii , H. Choritz
DOI: 10.1016/S0344-0338(11)80081-6
关键词: Biopsy 、 Internal medicine 、 Incidence (epidemiology) 、 Polycythemia vera 、 Chronic myelogenous leukemia 、 Fibrosis 、 Bone marrow 、 Myeloid 、 Myelofibrosis 、 Pathology 、 Gastroenterology 、 Medicine
摘要: The distribution and the development of fibrosis were evaluated from bone marrow biopsies patients with chronic myeloproliferative disorders (CMPD), regarding two groups patients: (1) 564 follow-up over a period up to twelve years observation time, (2) 1.787 diagnostic CMPD patients. Fibrosis was divided into three grades fiber increase: early myelosclerosis, myelofibrosis, advanced myelofibrosis. first group sequential BMB showed significant progress myelofibrosis in so-called "Chronic Megakaryocytic-Granulocytic Myelosis"--CMGM-, which corresponds Agnogenic Myeloid Metaplasia-AMM-in 72.4% (21/29 patients), as well CML megakaryocytic increase-CML.MI-in 39.2% (20/51). In second biopsies, only 30% CMGM cases no fibrosis. P. vera, 16.2% (18/111) developed later. This figure 4.3% (2/46) Primary Thrombocythemia. Increase megakaryocytes indicates high risk for developing fibrosis, combined reduced life expectancy.
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