Intake of flavonoids and risk of cancer in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study

摘要: Limited amount of evidence suggests that high intake flavonoids could be associated with decreased risk lung and colorectal cancer, but more studies are needed. In this prospective cohort study, we assessed the relation between intakes 26 from 5 subclasses; flavonols, flavones, flavanones, flavan-3-ols anthocyanidins, lung, prostate cancer. The study population consisted 2,590 middle-aged eastern Finnish men population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. mean was 131.0 +/- 214.7 mg/day. During follow-up time 16.2 years, 62 138 prostate, 55 cancers occurred. All cancer cases occurred among either current smokers (n = 50) or previous 12). After adjustment for age, examination body mass index, smoking status, pack-years smoking, physical activity alcohol, total fat, saturated fiber, vitamin C E, relative (RR) 0.27 (95% CI: 0.11-0.66) highest quarter flavonoid as compared lowest quarter. Out subclasses, flavonols were RR 0.29 0.11-0.78) 0.24 0.09-0.64), respectively. No association found. We conclude is in men.