The biology and evolution of polyspermy: insights from cellular and functional studies of sperm and centrosomal behavior in the fertilized egg

摘要: Recent studies of centrosome biogenesis, microtubule dynamics, and their management point to role in mediating conditions such as aging cancer. Centrosome dysfunction is also a hallmark pathological polyspermy. Polyspermy occurs when the oocyte penetrated by more than one sperm can be because an excess centrosomes compromises development. However, some taxa, multiple enter egg with no apparent adverse effect on zygote viability. Thus, taxa manage represent cases non-pathological While these two forms polyspermy have long been known, we argue that there limited understanding proximate ultimate processes underlie this taxonomic variation outcome studying could help uncover control role(s) during fertilization particular, but mitosis general. To encourage we: 1) describe differences polyspermy, 2) discuss mechanistic aspects reproductive biology may contribute different consequences 3) outline potential selective events lead evolution outcomes. We suggest novel insights into occur cooperative between evolutionary biologists focusing mechanisms generating fitness distribution all events. The consequent discoveries informative cancer along other centrosome-related diseases syndromes.