Amino acid metabolism in rat hippocampus during the period of brain growth spurt.

作者: Maria T. O. Govinatzki , Luciana S. Velleda , Vera M. T. Trindade , Fabiano M. Nagel , Denise Bueno

DOI: 10.1023/A:1027364918315

关键词: Amino acidBiologyBiosynthesisGlycineInternal medicineBiochemistryMetabolismLipid metabolismProtein biosynthesisLeucineAlanineEndocrinology

摘要: We studied protein synthesis, lipid synthesis and CO2 production by oxidation of glycine, alanine leucine slices rat hippocampus during the period brain growth spurt. The metabolism three amino acids decreased with age animals, A major reduction was observed in which 4 times higher at 7 days than 21 for all studied. Glycine to twice as high ten oxidation. pathway utilization incorporation into proteins. acid that had highest metabolic rate.

参考文章(29)
J. T. Tildon, L. M. Roeder, Transport of 3-hydroxy[3-14C]butyrate by dissociated cells from rat brain. American Journal of Physiology-cell Physiology. ,vol. 255, ,(1988) , 10.1152/AJPCELL.1988.255.2.C133
M C McKenna, L I Bezold, S J Kimatian, J T Tildon, Competition of glycerol with other oxidizable substrates in rat brain. Biochemical Journal. ,vol. 237, pp. 47- 51 ,(1986) , 10.1042/BJ2370047
M Tsacopoulos, AL Veuthey, SG Saravelos, P Perrottet, G Tsoupras, Glial cells transform glucose to alanine, which fuels the neurons in the honeybee retina The Journal of Neuroscience. ,vol. 14, pp. 1339- 1351 ,(1994) , 10.1523/JNEUROSCI.14-03-01339.1994
K. Krnjević, Chemical Nature of Synaptic Transmission in Vertebrates Physiological Reviews. ,vol. 54, pp. 418- 540 ,(1974) , 10.1152/PHYSREV.1974.54.2.418
Kohji Sato, Sigetaka Yoshida, Kazuko Fujiwara, Keiya Tada, Masaya Tohyama, Glycine cleavage system in astrocytes. Brain Research. ,vol. 567, pp. 64- 70 ,(1991) , 10.1016/0006-8993(91)91436-5
E. R. Chaplin, A. L. Goldberg, I. Diamond, Leucine oxidation in brain slices and nerve endings. Journal of Neurochemistry. ,vol. 26, pp. 701- 707 ,(1976) , 10.1111/J.1471-4159.1976.TB04440.X
D.S. Dunlop, W. van Elden, A. Lajtha, Optimal conditions for protein synthesis in incubated slices of rat brain Brain Research. ,vol. 99, pp. 303- 318 ,(1975) , 10.1016/0006-8993(75)90031-1
J. Tyson Tildon, Lois M. Roeder, Glutamine oxidation by dissociated cells and homogenates of rat brain: kinetics and inhibitor studies Journal of Neurochemistry. ,vol. 42, pp. 1069- 1076 ,(1984) , 10.1111/J.1471-4159.1984.TB12712.X
Lois M. Roeder, J. Tyson Tildon, Irene B. Williams, Transport of 2-deoxy-d-glucose by dissociated brain cells Brain Research. ,vol. 345, pp. 298- 305 ,(1985) , 10.1016/0006-8993(85)91006-6