A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL
作者： Peng Wang , Xi Yang , Liang Zhao , Dongxiao Liu , Junmao Liu
DOI: 10.1016/J.YEXCR.2019.05.034
关键词: Carcinogenesis 、 Cancer research 、 Biology 、 Long non-coding RNA 、 Cancer cell 、 Cancer 、 Cell migration 、 Cell culture 、 Cell 、 Downregulation and upregulation 、 Cell biology
摘要: Abstract Long non-coding RNAs (lncRNAs) are reported to play a significant role in various malignant tumors, yet their potential functions gastric cancer not clear. In this study, we found novel lncRNA, named TONSL-AS1, was downregulated tissues and cell lines compared with the normal. TONSL-AS1 inhibited migration, invasion proliferation SGC‐7901, MGC‐803 cells. Furthermore, could suppress tumorigenesis vivo. Mechanistically, TONSL-AS1's genomic neighboring gene TONSL, which as tumor gene, upregulated by TONSL. Additionally, positively associated TONSL tissues. Our study revealed that tumor-inhibiting effect of cells general, our results indicated works suppressor may be new therapeutic target for cancer.
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