Localization of the t(2;13) breakpoint of alveolar rhabdomyosarcoma on a physical map of chromosome 2.
作者： Frederic G. Barr , John Holick , Lynn Nycum , Jaclyn A. Biegel , Beverly S. Emanuel
DOI: 10.1016/0888-7543(92)90030-V
关键词: Biology 、 Somatic cell 、 Derivative chromosome 、 Chromosome 、 Rhabdomyosarcoma 、 Southern blot 、 Genetics 、 Alveolar rhabdomyosarcoma 、 Chromosomal translocation 、 Breakpoint
摘要: A characteristic translocation t(2;13)(q35;q14) has been previously identified in the pediatric soft tissue tumor alveolar rhabdomyosarcoma. We have assembled a panel of lymphoblast, fibroblast, and somatic cell hybrid lines with deletions unbalanced translocations involving chromosome 2 to develop physical map distal 2q region. Twenty-two probes were localized on this by Southern blot analysis mapping panel. The position these respect t(2;13) rhabdomyosarcoma breakpoint was then determined quantitative an line two copies derivative 13 one copy clones derived from line. demonstrate that is situated within interval delimited deletion fibroblast GM09892 t(X;2) GM11022. Furthermore, comparison our data linkage syntenic region mouse 1, we conclude most closely flanked loci INHA ALPI interval.
sci-hub.se 参考文章(37)
D Pribula-Conway, R Timpl, D Weil, E Passage, V C N'Guyen, M G Mattei, M L Chu, K Mann, R Deutzmann, Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen. American Journal of Human Genetics. ,vol. 42, pp. 435- 445 ,(1988)
V. Verga, S. Johnson, J. V. Higgins, T. W. Glover, B. K. Hall, Shirong Wang, Localization of the translocation breakpoint in a female with Menkes syndrome to Xq13.2-q13.3 proximal to PGK-1. American Journal of Human Genetics. ,vol. 48, pp. 1133- 1138 ,(1991)
T L Yang-Feng, K E Morrison, S T Reeders, M Mariyama, Sequence and localization of a partial cDNA encoding the human alpha 3 chain of type IV collagen. American Journal of Human Genetics. ,vol. 49, pp. 545- 554 ,(1991)
D J Drucker, S Asa, Glucagon gene expression in vertebrate brain. Journal of Biological Chemistry. ,vol. 263, pp. 13475- 13478 ,(1988) , 10.1016/S0021-9258(18)68261-4
Masanobu Obara, Mohinder S. Kang, Sylvie Rocher-Dufour, Alberto Kornblihtt, Jean Paul Thiery, Kenneth M. Yamada, Expression of the cell-binding domain of human fibronectin in E. coli FEBS Letters. ,vol. 213, pp. 261- 264 ,(1987) , 10.1016/0014-5793(87)81502-8
B S Emanuel, M Budarf, C Griffin, B Sellinger, Comparative mapping of the constitutional and tumor-associated 11;22 translocations. American Journal of Human Genetics. ,vol. 45, pp. 128- 139 ,(1989)
P S Henthorn, M Raducha, T Kadesch, M J Weiss, H Harris, Sequence and characterization of the human intestinal alkaline phosphatase gene. Journal of Biological Chemistry. ,vol. 263, pp. 12011- 12019 ,(1988) , 10.1016/S0021-9258(18)37886-4
S O Meakin, M L Breitman, L C Tsui, Structural and evolutionary relationships among five members of the human gamma-crystallin gene family. Molecular and Cellular Biology. ,vol. 5, pp. 1408- 1414 ,(1985) , 10.1128/MCB.5.6.1408
E.C. Douglass, M. Valentine, E. Etcubanas, D. Parham, B.L. Webber, P.J. Houghton, A.A. Green, A specific chromosomal abnormality in rhabdomyosarcoma Cytogenetic and Genome Research. ,vol. 45, pp. 148- 155 ,(1987) , 10.1159/000132446
W.T. Schroeder, L.C. Lopez, M.E. Harper, G.F. Saunders, Localization of the human glucagon gene (GCG) to chromosome segment 2q36----37. Cytogenetic and Genome Research. ,vol. 38, pp. 76- 79 ,(1984) , 10.1159/000132034