Radiofrequency ablation for eradication of renal tumor in a rabbit model by using a cooled-tip electrode technique.

摘要: Background:Radiofrequency ablation (RFA) has emerged as a potential alternative for surgery in clinical oncology. This animal experiment was conducted to evaluate the feasibility of RFA treatment renal tumor. Methods:Eighteen rabbits with implantation VX2 tumors were divided into two groups. Group A (n = 12) treated by using cooled-tip RF system at 30 W 80 180 seconds. B 6) received sham operation. The therapeutic efficacy evaluated survival rate, magnetic resonance imaging (MRI), and histology. Results:All animals group died within 3 months after tumor implantation. Total eradication achieved 10 12 (83.3%) A, which 5 survived longer than 6 (absolute eradication) another found free viable when killed (relative eradication). Two experienced local relapse, lung metastasis, or both. Six-month rate RFA-treated significantly higher (P < .01) that control rabbits. typical MRI appearances acute lesion consisted five characteristic concentric zones, corresponded central needle track (zone A), coagulation B), tissue C), peripheral hemorrhage D), inflammatory layer E) on Conclusions:RFA may become promising therapy is useful modality assessment ablation.