Strains of Respiratory Syncytial Virus: Implications for Vaccine Development

摘要: Within a few years after its discovery in 1957, respiratory syncytial virus (RSV) was shown to be the single most important pathogen of acute lower tract illness among infants and young children worldwide. In 1960’s 1970’s multiple attempts develop vaccine failed. The first formalin-inactivated, alum precipitated grown primary monkey kidney cells that evaluated four field trials (Chin et al. 1969; Fulginiti Kapikian Kim 1969). induced good serologic response RSV but failed protect vaccinee from infection and, vaccinees <2 yrs old experienced more severe disease than those not vaccinated. This increase serious is illustrated Table 1 for one trials. Live vaccines also (Belshe 1982; McKay 1988; Tyeryar, 1983; Wright 1976, 1982). Some strains reverted wild phenotype during clinical others induce an adequate antibody response. These failures have led researchers conclude better understanding host interaction needed chances successfully developing vaccine.