Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors.

摘要: The cellular sites and mechanisms of human cytomegalovirus (HCMV) latency are still poorly defined. Although evidence suggests that peripheral blood monocytes one site in the healthy carrier, it is unlikely represent a primary HCMV infection. Consequently, we have analysed CD34+ bone marrow progenitors, precursors monocytes, to determine whether they carriage normal virus carriers. For first time, demonstrate presence endogenous within progenitors absence lytic gene expression. These findings consistent with previous showing permissiveness myeloid cells for critically dependent on differentiation state cell.