Liver regeneration after partial hepatectomy in rat is more impaired in a steatotic liver induced by dietary fructose compared to dietary fat

摘要: Abstract Hepatic steatosis (HS) has a negative effect on liver regeneration, but different pathophysiologies of HS may lead to outcomes. Male Sprague-Dawley rats were fed high fructose (66% fructose; H-fruc), fat (54% fat; H-fat), or control chow diet for 4 weeks. Based hepatic triglyceride content and oil red O staining, developed in the H-fruc group, was less severe compared H-fat group. mRNA expression levels fatty acid synthase fructokinase increased those carnitine palmitoyltransferase-1 peroxisome proliferator-activated receptor-α decreased group Liver regeneration after 70% partial hepatectomy (PHx) evaluated by measuring increase postoperative mass PCNA-positive hepatocytes, impaired groups days 3 7. Serum tumor necrosis factor-α, interleukin-6 hepatocyte growth factor did not change significantly PHx. In contrast, serum TGF-β1 slightly lower day 1 level each 0, then gradually increased. However, PHx These results indicate that impairment is related cause, rather than degree, steatosis. This difference result from altered metabolic gene profiles potential dysregulation expression.