Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission
作者： Jinjin Zhang , Pan Xu , Youlei Wang , Meirong Wang , Hongbo Li
DOI: 10.1111/JCMM.12609
关键词: Astaxanthin 、 Cell biology 、 Apoptosis 、 Biology 、 Mitochondrion 、 Mitochondrial fission 、 Pulmonary fibrosis 、 Cytochrome c 、 Myofibroblast 、 Bcl-2-associated X protein
摘要: Promotion of myofibroblast apoptosis is a potential therapeutic strategy for pulmonary fibrosis. This study investigated the antifibrotic effect astaxanthin on promotion based dynamin-related protein-1 (Drp1)-mediated mitochondrial fission in vivo and vitro. Results showed that can inhibit lung parenchymal distortion collagen deposition, as well promote apoptosis. Astaxanthin demonstrated pro-apoptotic function myofibroblasts by contributing to fission, thereby leading increasing Drp1 expression enhancing translocation into mitochondria. Two specific siRNAs were used demonstrate necessary astaxanthin-induced myofibroblasts. Drp1-associated genes, such Bcl-2-associated X protein, cytochrome c, tumour suppressor gene p53 p53-up-regulated modulator apoptosis, highly up-regulated group compared with those sham group. revealed prevent fibrosis promoting through Drp1-dependent molecular pathway. Furthermore, provides value treatment.
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