Inhibition of nitric oxide synthesis inhibits rat sleep.

摘要: Abstract Previous findings indicate that nitric oxide (NO) may play a role in the regulation of sleep-wake activity. In rabbits, blocking production endogenous NO by synthase inhibitor, Nω-nitro- l -arginine ( -NAME) suppresses spontaneous sleep and interferes somnogenic actions interleukin 1. present experiments we extended our earlier work studying long-term effects -NAME treatment on activity including power spectra analyses electroencephalogram (EEG) rats. Rats implanted with EEG electrodes, brain thermistor, intracerebroventricular (i.c.v.) guide cannula were injected i.c.v. vehicle or 0.2, 1, 5 mg at light onset. separate experiments, rats intraperitoneally (i.p.) three times (50, 50, 100 mg/kg), 12-12 h apart. Both i.p. injections elicited decreases time spent NREMS REMS. After injection responses long-lasting; did not return to baseline even 72 after injection. delta-wave during (slow wave activity) was also suppressed 0.2 -NAME. Brain temperature slightly increased two lower doses -NAME, whereas there transient decrease Tbr Acute 50 mg/kg an immediate which lasted for ∼ 2 h. The second following induced biphasic but These results are accordance observations inhibition synthesis consistent hypothesis is involved maintenance normal