Tannic Acid preferentially targets estrogen receptor-positive breast cancer.
作者： Brian W. Booth , Beau D. Inskeep , Hiral Shah , Jang Pyo Park , Elizabeth J. Hay
DOI: 10.1155/2013/369609
关键词: Cancer cell 、 Medicine 、 Estrogen receptor 、 Cancer research 、 Caspase 8 、 Breast cancer 、 Cancer 、 Pathology 、 Caspase-9 、 Caspase 3 、 Apoptosis
摘要: Research efforts investigating the potential of natural compounds in fight against cancer are growing. Tannic acid (TA) belongs to class hydrolysable tannins and is found numerous plants foods. TA a potent collagen cross-linking agent; purpose this study was generate TA-cross-linked beads assess effects on breast cell growth. Collagen were stable at body temperature following crosslinking. Exposure with higher levels inhibited proliferation induced apoptosis normal cells. TA-induced involved activation caspase 3/7 9 but not 8. Breast cells expressing estrogen receptor more susceptible TA. Taken together results suggest that has become an anti-ER+ treatment or preventative agent.
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