Immunologic Control of Toxoplasma gondii Infection by CD8+ Lymphocytes: A Model for Class I MHC-Restricted Recognition of Intracellular Parasites
作者： Ricardo T. Gazzinelli , Eric Denkers , Frances Hakim , Alan Sher
DOI: 10.1007/978-1-4684-6814-4_36
关键词: Microbiology 、 Schistosoma mansoni 、 Major histocompatibility complex 、 Protozoa 、 Intracellular parasite 、 Toxoplasma gondii 、 Immunology 、 Antigen 、 CD8 、 Effector 、 Biology
摘要: Immunity against parasites (protozoa and helminths) has traditionally been thought to depend exclusively on CD4+ helper functions controlling B-cell (i.e., antibody) lymphokine-mediated effector mechanisms. It is only within the last decade that CD8+ lymphocytes have demonstrated display protective activity parasitic infections. As would be predicted, most CD8+-dependent mechanisms are directed intracellular infecting host cells expressing class I major histocompatibility complex (MHC) products. Nevertheless, there several examples of interacting with extra-cellular such as tachyzoites Toxoplasma gondii (Khan et al., 1988) or schistosomula Schistosoma mansoni (Butterworth 1979). In latter system, recognition dependent presence adsorbed MHC molecules parasite surface (Sher 1978). While killing protozoa parasitizing cells, environments affected organisms differ considerably. Because this, study parasite-CD8+ interactions provides some fascinating well highly relevant models for studying processing presentation foreign antigens by molecules.
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sci-hub.st 参考文章(41)
W. I. Morrison, B. M. Goddeeris, Cytotoxic T Cells in Immunity to Theileria parva in Cattle T-Cell Paradigms in Parasitic and Bacterial Infections. ,vol. 155, pp. 79- 93 ,(1990) , 10.1007/978-3-642-74983-4_6
G. M. Shearer, R. C. Gallo, R. Redfield, S. Z. Salahuddin, K. S. K. Tung, C. S. Via, D. C. Bernstein, A model for the selective loss of major histocompatibility complex self-restricted T cell immune responses during the development of acquired immune deficiency syndrome (AIDS). Journal of Immunology. ,vol. 137, pp. 2514- 2521 ,(1986)
C R Brown, R McLeod, Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection. Journal of Immunology. ,vol. 145, pp. 3438- 3441 ,(1990)
E Denkers, S Hieny, R T Gazzinelli, A Sher, F T Hakim, G M Shearer, CD8+ T cells from mice vaccinated against Toxoplasma gondii are cytotoxic for parasite-infected or antigen-pulsed host cells. Journal of Immunology. ,vol. 147, pp. 2310- 2316 ,(1991)
K H Ely, I A Khan, L H Kasper, A purified parasite antigen (p30) mediates CD8+ T cell immunity against fatal Toxoplasma gondii infection in mice. Journal of Immunology. ,vol. 147, pp. 3501- 3506 ,(1991)
E Y Denkers, S Hieny, R T Gazzinelli, P Caspar, A Sher, Bone marrow macrophages process exogenous Toxoplasma gondii polypeptides for recognition by parasite-specific cytolytic T lymphocytes. Journal of Immunology. ,vol. 150, pp. 517- 526 ,(1993)
A H Koniaris, J S Remington, C S Subauste, Murine CD8+ cytotoxic T lymphocytes lyse Toxoplasma gondii-infected cells. Journal of Immunology. ,vol. 147, pp. 3955- 3959 ,(1991)
M K Waldor, T L Vollmer, L Steinman, F K Conley, Depletion of T-4+ lymphocytes with monoclonal antibody reactivates toxoplasmosis in the central nervous system: a model of superinfection in AIDS. Journal of Immunology. ,vol. 138, pp. 3737- 3741 ,(1987)
Y Suzuki, J S Remington, Dual regulation of resistance against Toxoplasma gondii infection by Lyt-2+ and Lyt-1+, L3T4+ T cells in mice. Journal of Immunology. ,vol. 140, pp. 3943- 3946 ,(1988)
Alan Sher, Eric Martz, Mathew A. Vadas, Anthony E. Butterworth, Cytolytic T Lymphocytes Recognize Alloantigens on Schistosomula of Schistosoma Mansoni, but Fail to Induce Damage Journal of Immunology. ,vol. 122, pp. 1314- 1321 ,(1979)