Temporary inactivation of the dorsal entorhinal cortex impairs acquisition and retrieval of spatial information

摘要: We tested the effects of temporary inactivation dorsal entorhinal cortex on spatial discrimination using a conditioned cue preference (CCP) paradigm. The three phases procedure were: pre-exposure: unreinforced exploration center platform and two adjacent arms an eight-arm radial maze; training: rats were confined to ends alternate days - one arm always contained food other never food; testing: arms. Rats that received bilateral infusions saline into before training trials or test trial spent significantly more time in previously than food, demonstrating they had acquired able express information discriminated between maze In contrast, bilateral, intra-entorhinal muscimol, gamma-aminobutyric acid(a) (GABA(a)) agonist, either testing equal amounts arms, indicating failed acquire unable this information. Interactions hippocampus acquisition expression required for are discussed.