The Hyperpolarization-Activated HCN1 Channel Is Important for Motor Learning and Neuronal Integration by Cerebellar Purkinje Cells

摘要: In contrast to our increasingly detailed understanding of how synaptic plasticity provides a cellular substrate for learning and memory, it is less clear neuron's voltage-gated ion channels interact with plastic changes in strength influence behavior. We find, using generalized regional knockout mice, that deletion the HCN1 channel causes profound motor memory deficits swimming rotarod tasks. cerebellar Purkinje cells, which are key component circuit correctly timed movements, mediates an inward current stabilizes integrative properties cells ensures their input-output function independent previous history activity. suggest this nonsynaptic required accurate decoding input patterns thereby enables appropriately performance