Inducible nitric oxide synthase gene deletion exaggerates MAPK-mediated cyclooxygenase-2 induction by inflammatory stimuli.
作者： Brian D. Lamon , Rita K. Upmacis , Ruba S. Deeb , Hilal Koyuncu , David P. Hajjar
DOI: 10.1152/AJPHEART.00144.2010
关键词: Molecular biology 、 Cyclooxygenase 、 Nitric oxide 、 Vascular smooth muscle 、 Nitric oxide synthase 、 Inflammation 、 ATP synthase 、 Mitogen-activated protein kinase 、 Biology 、 MAPK/ERK pathway
摘要: Cyclooxygenase (COX)-2 and inducible nitric oxide (NO) synthase (iNOS) are responsive to a wide array of inflammatory stimuli, have been localized vascular smooth muscle cells (SMCs), in...
sci-hub.se 参考文章(57)
K.A. Pritchard, M.K. O'Banion, J.M. Miano, N. Vlasic, U.G. Bhatia, D.A. Young, M.B. Stemerman, Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. Journal of Biological Chemistry. ,vol. 269, pp. 8504- 8509 ,(1994) , 10.1016/S0021-9258(17)37223-X
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Christopher S. R. Baker, Roger J. C. Hall, Thomas J. Evans, Ariela Pomerance, Jacques Maclouf, Christophe Creminon, Magdi H. Yacoub, Julia M. Polak, Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 19, pp. 646- 655 ,(1999) , 10.1161/01.ATV.19.3.646
Sarah McClelland, Meinrad Gawaz, Elisabeth Kennerknecht, Carolin Sophie Ildiko Konrad, Susanne Sauer, Katrin Schuerzinger, Steffen Massberg, Desmond J. Fitzgerald, Orina Belton, Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse. Atherosclerosis. ,vol. 202, pp. 84- 91 ,(2009) , 10.1016/J.ATHEROSCLEROSIS.2008.04.016
Asifa Haider, Irene Lee, Jerzy Grabarek, Zbigniew Darzynkiewicz, Nicholas R. Ferreri, Dual Functionality of Cyclooxygenase-2 as a Regulator of Tumor Necrosis Factor–Mediated G1 Shortening and Nitric Oxide–Mediated Inhibition of Vascular Smooth Muscle Cell Proliferation Circulation. ,vol. 108, pp. 1015- 1021 ,(2003) , 10.1161/01.CIR.0000085211.97972.2C
Marcel Bassil, Yuan Li, Madhu B. Anand-Srivastava, Peroxynitrite inhibits the expression of Giα protein and adenylyl cyclase signaling in vascular smooth muscle cells American Journal of Physiology-heart and Circulatory Physiology. ,vol. 294, pp. 775- 784 ,(2008) , 10.1152/AJPHEART.00841.2007
Paolo Gresele, Stefania Momi, Pharmacologic Profile and Therapeutic Potential of NCX 4016, a Nitric Oxide‐releasing Aspirin, for Cardiovascular Disorders Cardiovascular Drug Reviews. ,vol. 24, pp. 148- 168 ,(2006) , 10.1111/J.1527-3466.2006.00148.X
Hai-Bing Peng, Peter Libby, James K. Liao, Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB Journal of Biological Chemistry. ,vol. 270, pp. 14214- 14219 ,(1995) , 10.1074/JBC.270.23.14214
Yusen Liu, Edward G. Shepherd, Leif D. Nelin, MAPK phosphatases — regulating the immune response Nature Reviews Immunology. ,vol. 7, pp. 202- 212 ,(2007) , 10.1038/NRI2035
M Raman, W Chen, M H Cobb, Differential regulation and properties of MAPKs. Oncogene. ,vol. 26, pp. 3100- 3112 ,(2007) , 10.1038/SJ.ONC.1210392