An in vitro immune response to penicillin.

摘要: The use of the in vitro system Mishell and Dutton (1), originally described for immune response dissociated mouse spleen cells to red cells, has contributed valuable information our understanding primary response. However, since cell is a complex possibly atypical antigen, there are obvious advantages extending with chemically defined haptens as antigens. Kettman (2) have demonstrated determinant trinitrophenyl (TNP) using TNP-coupled sheep immunogen, also shown that greatly enhanced when were taken from mice which had been immunized carrier, (3). Trowbridge et al. (4) obtained similar results hapten, hydroxy-nitroiodophenyl (NIP). Segal (5) observed dinitrophenyl group (DNP) lymph node explants.