Cancer cell-expressed immunoglobulins: CA215 as a pan cancer marker and its diagnostic applications.

摘要: Background RP215 was the first generated monoclonal antibody which recognizes specifically carbohydrate-associated epitope(s) localized in variable region of cancer cell-expressed immunoglobulin heavy chains, designated general as CA215. Clinical evaluations were performed to assess if can be utilized immunoassays determine serum levels CA215 among ovarian or cervical patients for monitoring purposes. Methods By using immunoassays, determined from and evaluated based on their respective clinical stages well conditions treatments. Results Multi-center trials with frozen specimens cancers efficacy RP215-based immunoassays. In case cancer, immunoassay kit has a sensitivity 46-68% compared 46-70% that corresponding CA125 kit. When both markers combined simultaneous patients, could high 72-87%. Further analysis revealed are correlated tumor progression surgical radio/chemo Conclusions The results these multi-center studies suggest is suitable pan marker ovarian/cervical maybe several others express detected human circulations.