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    Tumor and host genetics in diagnosis and risk stratification of aggressive B-cell lymphoma

    作者： Ahmet Dogan

    DOI:

    关键词: Immunology 、 Chromosomal translocation 、 Genome 、 Biology 、 Clone (B-cell biology) 、 Lymphoma 、 B-cell lymphoma 、 Phenotype 、 Genetics 、 Mechanism (biology) 、 Neoplastic cell

    摘要: Lymphomas are neoplasms caused by clonal proliferation of lymphoid cells. The neoplastic clone acquires survival advantage and escapes normal regulatory mechanism as a consequence gained genetic changes. These include mutations translocations affecting the genome cell and, sometimes, additional material introduced infectious agents such viruses. changes their phenotypic consequences have been one important determinants current lymphoma classifications risk stratification in B-cell lymphoma. (1, 2)

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    来源期刊
    • 2008 年,
    • Volume: , Issue: ,
    • Page:
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