NT-pro-BNP predicts worsening renal function in patients with chronic systolic heart failure.
作者： R. Pfister , J. Müller-Ehmsen , J. Hagemeister , M. Hellmich , E. Erdmann
DOI: 10.1111/J.1445-5994.2010.02203.X
关键词: Interquartile range 、 Medicine 、 Predictive value of tests 、 Renal function 、 Cardiology 、 Natriuretic peptide 、 Ejection fraction 、 Creatinine 、 Heart failure 、 Internal medicine 、 Outpatient clinic
摘要: Background: Worsening renal function (WRF) is frequently observed in patients with heart failure and associated worse outcome. The aim of this study was to examine the association cardiac serum marker N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) WRF. Methods: A total 125 consecutive a tertiary care outpatient clinic for prospectively underwent evaluation every 6 months. baseline NT-pro-BNP WRF analysed during follow up 18 months. Results: Twenty-eight (22.4%) developed (increase creatinine ≥0.3 mg/dL). Patients (2870 pg/mL, interquartile range (IQR) 1063–4765) had significantly higher values than without (547 pg/mL, IQR 173–1454). risk increased by 4.0 (95% CI 2.1–7.5) each standard deviation log NT-pro-BNP. In multivariable analysis including age, function, ejection fraction, New York Heart Association class diuretic dose, only diabetes were independent predictors WRF. At cut-off level 696 pg/mL, showed sensitivity 92.9% negative predictive value 96.4% WRF. Conclusion: strong predictor within 18 months systolic high value. Further studies are needed evaluate reno-protective strategies elevated
sci-hub.se 参考文章(35)
Patrick Jourdain, Guillaume Jondeau, François Funck, Pascal Gueffet, Alain Le Helloco, Erwan Donal, Jean F. Aupetit, Marie C. Aumont, Michel Galinier, Jean C. Eicher, Alain Cohen-Solal, Yves Juillière, Plasma Brain Natriuretic Peptide-Guided Therapy to Improve Outcome in Heart Failure: The STARS-BNP Multicenter Study Journal of the American College of Cardiology. ,vol. 49, pp. 1733- 1739 ,(2007) , 10.1016/J.JACC.2006.10.081
Anju Nohria, Vic Hasselblad, Amanda Stebbins, Daniel F. Pauly, Gregg C. Fonarow, Monica Shah, Clyde W. Yancy, Robert M. Califf, Lynne W. Stevenson, James A. Hill, Cardiorenal Interactions: Insights From the ESCAPE Trial Journal of the American College of Cardiology. ,vol. 51, pp. 1268- 1274 ,(2008) , 10.1016/J.JACC.2007.08.072
Roland R.J. van Kimmenade, James L. Januzzi, Aaron L. Baggish, John G. Lainchbury, Antoni Bayes-Genis, A. Mark Richards, Yigal M. Pinto, Amino-terminal pro-brain natriuretic Peptide, renal function, and outcomes in acute heart failure: redefining the cardiorenal interaction? Journal of the American College of Cardiology. ,vol. 48, pp. 1621- 1627 ,(2006) , 10.1016/J.JACC.2006.06.056
L. Burchill, E. Velkoska, R. G. Dean, R. A. Lew, A. I. Smith, V. Levidiotis, L. M. Burrell, Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression. Experimental Physiology. ,vol. 93, pp. 622- 630 ,(2008) , 10.1113/EXPPHYSIOL.2007.040386
Roland R.J. van Kimmenade, James L. Januzzi, Jaap A. Bakker, Alphonse J. Houben, Roger Rennenberg, Abraham A. Kroon, Harry J.G.M. Crijns, Marja P. van Dieijen-Visser, Peter W. de Leeuw, Yigal M. Pinto, Renal clearance of B-type natriuretic peptide and amino terminal pro-B-type natriuretic peptide a mechanistic study in hypertensive subjects. Journal of the American College of Cardiology. ,vol. 53, pp. 884- 890 ,(2009) , 10.1016/J.JACC.2008.11.032
Roman Pfister, Dajana Tan, Jaimy Thekkanal, Martin Hellmich, Chistian Alfons Schneider, Predictors of elevated NT-pro-BNP in cardiovascular patients without acute heart failure International Journal of Cardiology. ,vol. 131, pp. 277- 280 ,(2009) , 10.1016/J.IJCARD.2007.07.047
Theresa Majalahti, Maria Suo-Palosaari, Balázs Sármán, Nina Hautala, Sampsa Pikkarainen, Heikki Tokola, Olli Vuolteenaho, Jun Wang, Pierre Paradis, Mona Nemer, Heikki Ruskoaho, Cardiac BNP gene activation by angiotensin II in vivo. Molecular and Cellular Endocrinology. ,vol. 273, pp. 59- 67 ,(2007) , 10.1016/J.MCE.2007.05.003
C. Geisberg, J. Butler, Addressing the challenges of cardiorenal syndrome. Cleveland Clinic Journal of Medicine. ,vol. 73, pp. 485- 491 ,(2006) , 10.3949/CCJM.73.5.485
Ramesh de Silva, Nikolay P. Nikitin, Klaus K.A. Witte, Alan S. Rigby, Huan Loh, Anthony Nicholson, Sunil Bhandari, Andrew L. Clark, John G.F. Cleland, Effects of applying a standardised management algorithm for moderate to severe renal dysfunction in patients with chronic stable heart failure. European Journal of Heart Failure. ,vol. 9, pp. 415- 423 ,(2007) , 10.1016/J.EJHEART.2006.10.003
Kevin Damman, Gerjan Navis, Adriaan A. Voors, Folkert W. Asselbergs, Tom D.J. Smilde, John G.F. Cleland, Dirk J. van Veldhuisen, Hans L. Hillege, Worsening Renal Function and Prognosis in Heart Failure: Systematic Review and Meta-Analysis Journal of Cardiac Failure. ,vol. 13, pp. 599- 608 ,(2007) , 10.1016/J.CARDFAIL.2007.04.008