Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy
作者： Nicola M. Tomas , Laurence H. Beck , Catherine Meyer-Schwesinger , Barbara Seitz-Polski , Hong Ma
关键词: Antigen 、 Antibody 、 Thrombospondin 、 Autoantibody 、 Glomerulonephritis 、 Immunohistochemistry 、 Autoimmune disease 、 Immunology 、 Medicine 、 Blot
摘要: Background Idiopathic membranous nephropathy is an autoimmune disease. In approximately 70% of patients, it associated with autoantibodies against the phospholipase A2 receptor 1 (PLA2R1). Antigenic targets in remaining patients are unknown. Methods Using Western blotting, we screened serum samples from idiopathic nephropathy, other glomerular diseases, and healthy controls for antibodies human native proteins. We partially purified a putative new antigen, identified this protein by means mass spectrometry digested peptides, validated results analysis recombinant expression, immunoprecipitation, immunohistochemical analysis. Results Serum 6 44 European cohort 9 110 Boston anti-PLA2R1–negative recognized that was 250 kD size. None 74 memb...
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