A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms

作者: Tian Liu , Xueli Liu , Yunmei Chen , Rongling Wu

DOI: 10.1186/1742-4682-4-5

关键词: NeuroscienceCircadian rhythmBacterial circadian rhythmsGeneCircadian clock geneGeneticsBiologyQuantitative trait locusSystems biologyFunctional mapping

摘要: Background Genes that control circadian rhythms in organisms have been recognized, but difficult to detect because behavior comprises periodically dynamic traits and is sensitive environmental changes.

参考文章(32)
Shigehiro Ohdo, Satoru Koyanagi, Hinako Suyama, Shun Higuchi, Hironori Aramaki, Changing the dosing schedule minimizes the disruptive effects of interferon on clock function. Nature Medicine. ,vol. 7, pp. 356- 360 ,(2001) , 10.1038/85507
D. Gonze, J. Halloy, A. Goldbeter, Deterministic versus stochastic models for circadian rhythms. Journal of Biological Physics. ,vol. 28, pp. 637- 653 ,(2002) , 10.1023/A:1021286607354
Bruce Walsh, Michael Lynch, Genetics and Analysis of Quantitative Traits ,(1996)
Alex A. R. Webb, The physiology of circadian rhythms in plants New Phytologist. ,vol. 160, pp. 281- 303 ,(2003) , 10.1046/J.1469-8137.2003.00895.X
Joseph S. Takahashi, Circadian clocks a la CREM Nature. ,vol. 365, pp. 299- 300 ,(1993) , 10.1038/365299A0
Rongling Wu, Min Lin, Functional mapping — how to map and study the genetic architecture of dynamic complex traits Nature Reviews Genetics. ,vol. 7, pp. 229- 237 ,(2006) , 10.1038/NRG1804
Steven M. Reppert, David R. Weaver, Coordination of circadian timing in mammals Nature. ,vol. 418, pp. 935- 941 ,(2002) , 10.1038/NATURE00965
Mehdi Tafti, Brice Petit, Didier Chollet, Elisabeth Neidhart, Fabienne de Bilbao, Jozsef Z Kiss, Philip A Wood, Paul Franken, Deficiency in short-chain fatty acid β-oxidation affects theta oscillations during sleep Nature Genetics. ,vol. 34, pp. 320- 325 ,(2003) , 10.1038/NG1174
Didier Gonze, José Halloy, Jean-Christophe Leloup, Albert Goldbeter, Stochastic models for circadian rhythms: effect of molecular noise on periodic and chaotic behaviour. Comptes Rendus Biologies. ,vol. 326, pp. 189- 203 ,(2003) , 10.1016/S1631-0691(03)00016-7