Production of multiple emulsions for drug delivery systems by repeated SPG membrane homogenization: Influence of mean pore size, interfacial tension and continuous phase viscosity
作者： Goran T. Vladisavljević , Masataka Shimizu , Tadao Nakashima
DOI: 10.1016/J.MEMSCI.2006.08.003
关键词: Surface tension 、 Membrane 、 Porous glass 、 Chemical engineering 、 Membrane emulsification 、 Extrusion 、 Particle size 、 Materials science 、 Emulsion 、 Chromatography 、 Shear stress
摘要: Abstract Multiple water-in-oil-in-water (W/O/W) emulsions for drug delivery systems were produced by extruding a coarse W/O/W emulsion five times under pressure of 70–150 kPa through Shirasu Porous Glass (SPG) membrane with mean pore size 5.4, 7.6, 10.7, 14.8, and 20.3 μm. The encapsulation efficiency marker (CaNa 2 -EDTA) determined inductively coupled plasma (ICP) emission spectrophotometer was 83–85% in the products containing 30 vol.% inner droplets 30–50 vol.% outer drops. ratio particle to after extrusions decreased from 1.25 0.68 as increased 5.4 20.3 μm at wall shear stress continuous phase pores 200 Pa. resultant increasing viscosity decreasing size. same multiple prepared direct extrusion W/O SPG into stirring 3.46 independent on At low viscosity, uniform span values 0.28–0.34 very high transmembrane fluxes exceeding 200 m 3 m −2 h −1 .
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