Dioxygenase- and monooxygenase-catalysed synthesis of cis -dihydrodiols, catechols, epoxides and other oxygenated products

作者: Louise C. Nolan , Kevin E. O’Connor

DOI: 10.1007/S10529-008-9791-5

关键词: MonooxygenaseProtein engineeringChemistryDirected evolutionBiocatalysisEpoxideDioxygenaseEnzymeOxidase testStereochemistryOrganic chemistry

摘要: Oxidoreductases are an emerging class of biotechnologically relevant enzymes due to their regio- and stereo-specificity. The selective oxygenation aromatic compounds by oxidoreductases has received much attention a wide range reactions have been documented using these from various microbial sources. This review gives overview dioxygenase, monooxygenase oxidase that manipulated for the synthesis products such as cis-dihydrodiols, catechols, epoxides other oxygenated products. use protein engineering its advancement in recombinant is also discussed.

参考文章(68)
Lawrence P. Wackett, C. Douglas Hershberger, Biocatalysis and biodegradation: microbial transformation of organic compounds Published in <b>2001</b> in Washington (D.C.) by ASM press. ,(2001) , 10.1128/9781555818036
Vlada B. Urlacher, Rolf Schmid, Modern biooxidation : enzymes, reactions and applications Wiley-VCH. ,(2007)
Tim Bugg, Introduction to Enzyme and Coenzyme Chemistry Blackwell Publishing Ltd.. ,(2004) , 10.1002/9781444305364
A. Schmid, J. S. Dordick, B. Hauer, A. Kiener, M. Wubbolts, B. Witholt, Industrial biocatalysis today and tomorrow Nature. ,vol. 409, pp. 258- 268 ,(2001) , 10.1038/35051736
Hyun Joo, Zhanglin Lin, Frances H. Arnold, Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation. Nature. ,vol. 399, pp. 670- 673 ,(1999) , 10.1038/21395
Derek R. Boyd, Narain D. Sharma, Nigel I. Bowers, Howard Dalton, Mark D. Garrett, John S. Harrison, Gary N. Sheldrake, Dioxygenase-catalysed oxidation of disubstituted benzene substrates : benzylic monohydroxylation versus aryl cis-dihydroxylation and the meta effect Organic and Biomolecular Chemistry. ,vol. 4, pp. 3343- 3349 ,(2006) , 10.1039/B608417F
Andreas Schmid, Karin Hofstetter, Hans-Jürgen Feiten, Frank Hollmann, Bernard Witholt, Integrated Biocatalytic Synthesis on Gram Scale: The Highly Enantioselective Preparation of Chiral Oxiranes with Styrene Monooxygenase Advanced Synthesis & Catalysis. ,vol. 343, pp. 732- 737 ,(2001) , 10.1002/1615-4169(200108)343:6/7<732::AID-ADSC732>3.0.CO;2-Q