Emerging Critical Role of Molecular Testing in Diagnostic Genitourinary Pathology

摘要: Context The unprecedented advances in cancer genetics and genomics are rapidly affecting clinical management diagnostics solid tumor oncology. Molecular is now an integral part of routine patients with lung, colon, breast cancer. In sharp contrast, molecular biomarkers have been largely excluded from current algorithms urologic malignancies. Objective To discuss promising candidate that may soon make their transition to the realm genitourologic need for new treatment alternatives can improve upon modest outcome so far several types evident. Well-validated prognostic help clinicians identify early aggressive lacking. Identifying robust predictive will stratify response emerging targeted therapeutics another crucially needed development. A compiled review salient studies addressing topic could be helpful focusing future efforts. Data sources PubMed (US National Library Medicine) search published following terms was conducted: , therapy theranostics urinary bladder prostate adenocarcinoma renal cell carcinoma . Articles large cohorts multivariate analyses were given preference. Conclusions Our recent understanding complex alterations involved development progression malignancies yielding novel diagnostic tools opening doors experimental therapies these prevalent, frequently lethal tumors.