Phosphorylation of the androgen receptor in a human prostate tumor cell line
作者： Jacoba van Laar
DOI:
关键词: Thyroid hormone receptor 、 Monoclonal antibody 、 LNCaP 、 Androgen receptor 、 Androgen 、 Biology 、 Receptor 、 Polyclonal antibodies 、 Molecular biology 、 Phosphorylation
摘要: textabstractThe aim of the study described in this thesis was to deterntine whether androgen receptor is a phosphoprotein, resembling respect other members the steroid/vitamin D /thyroid hormone receptor fantily. Furthermore, it investigated whether androgen undergoes hormone-dependent phosphorylation For all studies thesis, human LNCaP (Lymp Node Carcinoma of Prostate) cell line used. The these cells was characterized with molecular mass and ligand-binding properties (Chapter 3). The characterization receptor-specific polyclonal antibodies, which are useful tools for studies, Chapter 4. Studies on androgen are presented Chapters 5 6. In addition to polyclonal an monoclonal antibody has been used for studies. preparation briefly in 5. A detailed description generation this antibody elsewhere (Zegers eta!, 1991).
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