Anti-inflammatory drugs and renal synthesis of prostaglandins and thromboxane in patients with systemic lupus erythematosus
作者： C. Patrono , G. Ciabattoni , G. A. Cinotti , B. M. Simonetti , A. Pierucci
DOI: 10.1007/978-94-010-9775-8_41
关键词: Medicine 、 Cyclooxygenase 、 Anti-inflammatory 、 Prostaglandin 、 In patient 、 Thromboxane-A synthase 、 Platelet 、 Prostacyclin 、 Pharmacology 、 Thromboxane
摘要: Prostaglandin (PG) I2 or prostacyclin and thrombaxane (Tx) A2 are labile oxygenated metabolites of arachidonate with contrasting effects on platelet function, vascular tone glomerular function1,2. In humans the corresponding stable hydration products, 6-keto-PGF1α TxB2 respectively, synthesized by renal cortical microsomes3, represent most abundant cyclooxygenase products in isolated glomeruli4 can be measured urine5,6.
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