The effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets.
作者： Lixing Lao , Grant Zhang , Richard H Wong , Aaron K Carter , Richard L Wynn
DOI: 10.1016/S0091-3057(02)01069-9
关键词: Acupuncture point 、 Anesthesia 、 Electroacupuncture 、 Nausea 、 Metoclopramide 、 Antiemetic 、 Ondansetron 、 Droperidol 、 Acupuncture 、 Medicine
摘要: The effect of electroacupuncture (EA) on cyclophosphamide-induced emesis in ferrets was studied at acupuncture point Neiguan (P6) with various electrical stimulation parameters (5–100 Hz, 1.5–3 V, 5–20 min, n=6/group). combination therapy EA (100 1.5 V and 10 min) the lower doses ondansetron (0.04 mg/kg), droperidol (0.25 mg/kg) metoclopramide (2.24 significantly reduced total number emetic episodes by 52%, 36% 73%, respectively, as well first phase compared to sham control (P<.01). These EA/drug combinations also showed a significant preventing either or drug alone (P<.05). present study suggests that may be useful an adjunctive treatment chemotherapy-induced emesis.
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