作者: Qian Chen , Lanlan Lv , Meng Yu , Yanhui Shi , Yuling Li
DOI: 10.1039/C3RA42990C
关键词: Medicinal chemistry 、 Hydroamination 、 Catalysis 、 Bromide 、 Homogeneous catalysis 、 Reactivity (chemistry) 、 Organic chemistry 、 Phenylacetylene 、 Markovnikov's rule 、 Carbene 、 Chemistry
摘要: A series of chelating NHC–palladium complexes with different alkane-bridges the type Pd[NHC–(CH2)n–NHC]X2 (X = Br or Cl, n 2–4) were synthesized, where NHC is a triazolyl-N-heterocyclic carbene donor ligand. The bromide 2 and 3 characterized by X-ray crystallography. effects length bridge halide ligand on catalytic reactivity in hydroamination reaction investigated. best performance was observed propylene-bridged Pd–NHC complex 2. phenylacetylene 4-methylphenylacetylene various substituted anilines catalyzed yielded only Markovnikov addition products good yield. Interestingly, this homogenous catalyst can be reused three times without significant loss activity.