Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease

作者: Alaganandam Kumaran , Cheng Chang Ho , Lucy Sun Hwang

DOI: 10.1016/J.JFDA.2017.01.007

关键词: RutinToxicityHyperosideApoptosisBiochemistryAmyloid precursor proteinIsoorientinPathogenesisBiologyOrientin

摘要: … Amyloid β peptide (Aβ) has been identified as a possible source of oxidative stress in the … and toxic effects associated with Aβ-induced oxidative stress. As a result of strong interest to …

参考文章(40)
Astrid Gutierrez-Zepeda, Ross Santell, Zhixin Wu, Marishka Brown, YanJue Wu, Ikhlas Khan, Christopher D Link, Baolu Zhao, Yuan Luo, Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neuroscience. ,vol. 6, pp. 54- 54 ,(2005) , 10.1186/1471-2202-6-54
Xiongwei Zhu, Arun K. Raina, Hyoung-Gon Lee, Mark Chao, Akihiko Nunomura, Massimo Tabaton, Robert B. Petersen, George Perry, Mark A. Smith, Oxidative Stress and Neuronal Adaptation in Alzheimer Disease: The Role of SAPK Pathways Antioxidants & Redox Signaling. ,vol. 5, pp. 571- 576 ,(2003) , 10.1089/152308603770310220
Uendra Kumar, Donna M. Dunlop, J. Steven Richardson, The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F International Journal of Neuroscience. ,vol. 79, pp. 185- 190 ,(1994) , 10.3109/00207459408986079
Da-wei Zhan, Rui-tian Liu, Shao-wei Wang, Yu-Jiong Wang, Ya-jing Su, Wei-wei Zhou, Shi-gao Yang, Ran Zhang, Min Zhao, Ya-nan Li, Zi-ping Zhang, Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. Neurotoxicology. ,vol. 33, pp. 482- 490 ,(2012) , 10.1016/J.NEURO.2012.03.003
Debajyoti Mukherjee, Tarak Nath Khatua, P. Venkatesh, B.P. Saha, Pulok K. Mukherjee, Immunomodulatory potential of rhizome and seed extracts of Nelumbo nucifera Gaertn. Journal of Ethnopharmacology. ,vol. 128, pp. 490- 494 ,(2010) , 10.1016/J.JEP.2010.01.015
Henry Wing-Cheung Leung, Chao-Lin Kuo, Wen-Hui Yang, Chia-Hsien Lin, Hong-Zin Lee, Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis European Journal of Pharmacology. ,vol. 534, pp. 12- 18 ,(2006) , 10.1016/J.EJPHAR.2006.01.021
Cheng Chang Ho, Alaganandam Kumaran, Lucy Sun Hwang, Bio-assay guided isolation and identification of anti-Alzheimer active compounds from the root of Angelica sinensis. Food Chemistry. ,vol. 114, pp. 246- 252 ,(2009) , 10.1016/J.FOODCHEM.2008.09.046
Soo Jung Choi, Mi Jeong Kim, Ho Jin Heo, Hye Kyung Kim, Bumshik Hong, Chang-Ju Kim, Byung-Gee Kim, Dong Hoon Shin, Protective effect of Rosa laevigata against amyloid beta peptide-induced oxidative stress Amyloid. ,vol. 13, pp. 6- 12 ,(2006) , 10.1080/13506120500535636