Transport and processing of lysosomal enzymes by smooth muscle cells and endothelial cells
作者： Andrej Hasilik , Bruno Voss , Kurt Von Figura
DOI: 10.1016/0014-4827(81)90352-9
关键词: Cell biology 、 Intracellular 、 Cell type 、 Secretion 、 Enzyme 、 Biology 、 Mannose 6-phosphate receptor 、 Antibody 、 Cell 、 Mannose 、 Biochemistry
摘要: Abstract The distribution of lysosomal enzymes between the cells and medium, their presence at cell surface intracellular processing as well ability to take up from medium were compared in cultured human smooth muscle cells, endothelial skin fibroblasts. Common three types is proteolytical surface. relative secretion retention varies among studied, being highest cells. Whereas secreted by any are efficiently taken fibroblasts via a mechanism sensitive mannose 6-phosphate, differ medium. Unlike unable internalize urinary α-N-acetylglucosaminidase antibodies bound surface-associated β-hexosaminidase.
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